Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials 4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ
Top Ten Searches
brca1 prostate-specific antigen sclc fobt egd bmi dysplasia hematologic ovarian hccYour Article Summary
See Latest ArticlesTNF superfamily gene polymorphism as prognostic factor in early breast cancer
Journal of Cancer Research & Clinical Oncology, 11/10/09
Jung JH et al. – The TNFSF10 (rs1131532) polymorphism was identified as a possible prognostic factor of survival in patients with operated invasive breast cancer.
Methods- The genomic DNA extracted from paraffin-embedded tumor-free tissue or blood, and 12 single nucleotide polymorphisms (SNPs) of 11 apoptosis-related genes in apoptosis pathway determined using aSequenom MassARRAY system
- Median follow-up of 53.4 (range 2.9–205.9) mos
- 37 relapses and 22 deaths occurred
- Among target polymorphisms, tumor necrosis factor superfamily member 10 gene polymorphism (TNFSF10 rs1131532) in recessive model of T allele and prostaglandin-endoperoxide synthase 2 gene polymorphism (PTGS2 rs5275) in dominant model of C allele were associated with survival in log-rank test
- TT genotype of TNFSF10 (rs1131532) was also significantly correlated with a lower disease-free, distant disease-free, and overall survival in a multivariate analysis (HR = 3.304, 4.757, and 6.459; respectively), while PTGS2 rs5275 was only associated with higher distant disease-free survival (HR = 0.302)
- No clinicopathologic difference observed according to genotypes of these 2 polymorphisms
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Gene-expression-based analysis of local and metastatic neuroblastoma variants reveals a set of genes associated with tumor progression in neuroblastoma patients
International Journal of Cancer, 12/15/09
BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer
International Journal of Cancer, 12/15/09
Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells
International Journal of Cancer, 12/15/09
Today in Breast...keeping you current
Receive free subspecialty "5-minute updates" via email
BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer
International Journal of Cancer, 12/15/09
Systematic Review: Comparative Effectiveness of Core-Needle and Open Surgical Biopsy to Diagnose Breast Lesions
Annals of Internal Medicine, 12/15/09
Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells
Carcinogenesis, 12/15/09
Sponsor
Article Search
Sponsor
Sponsor