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See Latest ArticlesAnalysis of the expression of hyaluronan in intraductal and invasive carcinomas of the breast
Journal of Cancer Research & Clinical Oncology, 11/10/09
Corte MD et al. – Our study indicates a proportionally higher area of hyaluronan expression in DCIS with a microinvasive component than in pure DCIS, suggesting a key role of this glycosaminoglycan in the early invasive phase of breast carcinomas. Thus, hyaluronan could play an important function in determining the migratory phenotype of cancer cells. Larger size tumors appear to demonstrate an intricate balance between hyaluronan synthesis and degradation, thus conditioning intratumoral heterogeneity in the hyaluronan metabolism.
Methods- Hyaluronan expression evaluated by histochemical techniques in 42 cases of pure DCIS, in 15 cases of DCIS with microinvasive component, and in 32 cases of invasive ductal carcinoma of breast
- Staining results evaluated by calculating percentage of stained areas by means of specific software program
- Results show higher values of hyaluronan expression in invasive breast carcinomas [median of percentage of stained areas 41.1 (range 8–69.2)] and in DCIS with a microinvasive component [48.6 (16.8–62.8)] than in pure DCIS [14.5 (1–44.4)]
Today in Basic Science/Genetics...keeping you current
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Targeted proteasome inhibition by Velcade induces apoptosis in human mesothelioma and breast cancer cell lines
Cancer Chemotherapy and Pharmacology, 12/15/09
Differential Thymidylate Synthase Expression in Different Variants of Large-Cell Carcinoma of the Lung
Clinical Cancer Research, 12/15/09
miR-195 and miR-483-5p Identified as Predictors of Poor Prognosis in Adrenocortical Cancer
Clinical Cancer Research, 12/15/09
Today in Breast...keeping you current
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Life expectancy of screen-detected invasive breast cancer patients compared with women invited to the Nijmegen screening program
Cancer, 12/15/09
Targeted proteasome inhibition by Velcade induces apoptosis in human mesothelioma and breast cancer cell lines
Cancer Chemotherapy and Pharmacology, 12/15/09
The process of deciding about prophylactic surgery for breast and ovarian cancer: Patient questions, uncertainties, and communication
American Journal of Medical Genetics, 12/15/09
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