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Legakis I et al. – Ghrelin is a growth hormone–releasing acylated peptide found to be an appetite stimulant and low levels of it are detected in cachexia. The aim of the present study was to investigate the plasma ghrelin levels in cancer patients with a low performance status and weight loss and compare them with those of healthy individuals without weight loss. The notable reduction of ghrelin levels might be due to the severity and progression of the disease.

Exclusive Author Commentary
G.P. Stathopoulos, 11/24/09

Dear Sirs, Thank you for giving our work the opportunity to be assesible and recognised throuugh your up-to-date index of articles to a wide range of readers. Considering our results, we beleive that the significant reduction of circulating Ghrelin levels signify the evolution of the underlined disease and is further augmented by the fact that no correlation was found Ghrelin levels and the histological type of malignancy. In that respect, it is reasonable to be considered as an indicator of disease activity.

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