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A Throbbing Pain in the Head: Trastuzumab-induced Migraine
Anticancer Research, 11/06/09
Van Rooij F et al. – Trastuzumab, an epidermal growth factor receptor inhibitor, is used in the treatment of both early–stage and metastatic breast cancer. In general it is well tolerated, with a flu–like syndrome occurring frequently a few hours after administration, including symptoms such as fever, sweating, skin rash, nausea and headache. A migraineous headache however has never been described as an adverse event. Here the authors present a patient in whom a strong relationship between trastuzumab infusion and a migraineous headache syndrome was present, without evidence of metastatic disease. Treatment with corticosteroids for the infusion–related complaints resulted in significant pain relief.
Today in Pharmacology/Therapy...keeping you current
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Activity of fulvestrant in HER2-overexpressing advanced breast cancer
Annals of Oncology, 11/06/09
Randomized phase II study of gemcitabine administered at a fixed dose rate or in combination with cisplatin, docetaxel, or irinotecan in patients with metastatic pancreatic cancer
Journal of Clinical Oncology, 11/02/09
Comparison of neurocognitive functioning in children previously randomly assigned to intrathecal methotrexate compared with triple intrathecal therapy for the treatment of childhood acute lymphoblastic leukemia
Journal of Clinical Oncology, 11/09/09
Today in Side Effects...keeping you current
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Phase III, randomized, double-blind, placebo-controlled evaluation of pregabalin for alleviating hot flashes
Journal of Clinical Oncology, 11/12/09
Casopitant improves the quality of life in patients receiving highly emetogenic chemotherapy
Supportive Care in Cancer, 11/06/09
Long-Term Evaluation of Ifosfamide-Related Nephrotoxicity in Children
Journal of Clinical Oncology, 10/26/09
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