Oncology Medical News about chronic myeloid leukemia

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A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells
Leukemia, 11/09/09

Rix U et al. – In contrast to dasatinib and bosutinib, INNO–406 does not inhibit all SRC kinases and most TEC family kinases and is therefore expected to elicit fewer side effects. Altogether, these properties may make INNO–406 a valuable component in the drug arsenal against CML.

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Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete cytogenetic response, a study of the GIMEMA CML WP
Blood, 10/09/09 Relevance Score: 82%

Epidemiological study on survival of chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) patients with BCR-ABL T315I mutation
Blood, 11/06/09 Relevance Score: 81%

SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia
Genes, Chromosomes and Cancer, 10/28/09 Relevance Score: 81%

Novartis drug Tasigna meets primary endpoint in pivotal trial against Glivec as first-line treatment in chronic myeloid leukemia patients
Novartis, 10/21/09 Relevance Score: 81%

Dasatinib treatment of chronic phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations
Blood, 10/02/09 Relevance Score: 81%