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Hsa-mir-125b-2 is highly expressed in childhood ETV6/RUNX1 (TEL/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53
Leukemia, 11/09/09

Gefen N et al. – Knockdown of the endogenous miR–125b in the ETV6/RUNX1 leukemia cell line REH increased apoptosis after Doxorubicin and Staurosporine treatments. P53 protein levels were not altered by miR–125b. Together, these results suggest that the expression of hsa–mir–125b–2 in ETV6/RUNX1 ALL provides survival advantage to growth inhibitory signals in a p53–independent manner.

Exclusive Author Commentary
S Izraeli, 11/09/09

We also show that miR-125b is NOT a direct target of ETV6/RUNX1 (TEL/AML1) fusion gene. This finding suggests that miR-125b is an independent event that cooperates with ETV6/RUNX1 in the pathogenesis of this most common childhood leukemia

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Daunorubicin Versus Mitoxantrone Versus Idarubicin as Induction and Consolidation Chemotherapy for Adults With Acute Myeloid Leukemia: The EORTC and GIMEMA Groups Study AML-10
Journal of Clinical Oncology, 10/23/09 Relevance Score: 91%

Acute myeloid leukemia with mutated NPM1: diagnosis, prognosis and therapeutic perspectives
Current Opinion in Oncology, 10/14/09 Relevance Score: 90%

Genetic lesions in chronic lymphocytic leukemia: clinical implications
Current Opinion in Oncology, 10/14/09 Relevance Score: 89%

Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete cytogenetic response, a study of the GIMEMA CML WP
Blood, 10/09/09 Relevance Score: 89%

Minor histocompatibility antigens-targets of graft versus leukemia responses
International Journal of Hematology, 10/07/09 Relevance Score: 89%