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High Expression of the PAX3-FKHR Oncoprotein Is Required to Promote Tumorigenesis of Human Myoblasts
American Journal of Pathology, 11/09/09

Xia SJ et al. – RNA interference experiments in myoblast–derived tumor and ARMS cells revealed that high PAX3–FKHR expression plays a crucial role in regulating proliferation, transformation, and differentiation. These findings support the premise that high PAX3–FKHR–expressing cells are selected during tumorigenesis.

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