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See Latest ArticlesPhase I dose-finding study of paclitaxel with panitumumab, carboplatin and intensity-modulated radiotherapy in patients with locally advanced squamous cell cancer of the head and neck
Annals of Oncology, 11/10/09
Wirth LJ et al. – Panitumumab, carboplatin, paclitaxel and IMRT are well tolerated and appear highly active in the treatment of SCCHN.
Methods- Phase I dose-finding study investigated escalating doses of paclitaxel (Taxol) given concurrently with panitumumab, carboplatin and intensity-modulated radiotherapy (IMRT) for stage III–IVB SCCHN
- Untreated patients with oral cavity, oropharynx, larynx, hypopharynx or unknown primaries eligible
- Additional eligibility criteria included measurable disease, good performance status and no contraindication to therapy
- Patients received weekly fixed doses of panitumumab and carboplatin plus escalating doses of paclitaxel with IMRT
- 19 patients enrolled on to 2 dose levels (DLs): weekly paclitaxel 15 mg/m2 (n = 3) and 30 mg/m2
- 1 dose-limiting toxicity occurred in DL 2, which was declared maximum tolerated dose
- All patients experienced mucositis, primarily grade 3 or more
- Oral pain, xerostomia, dysphagia, weight loss, dermatitis, nausea and acneiform rash were frequent
- All patients had partial response according to RECIST, whereas overall complete clinical response rate was 95%
- Median follow-up of 21 months, 18 of 19 patients (95%) remained disease free
Today in Diagnostics/Radiology...keeping you current
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Diagnosis of platelet-type von Willebrand disease by flow cytometry
Haematologica, 12/09/09
Magnetic Resonance Imaging of Mesenchymal Stem Cells Homing to Pulmonary Metastases Using Biocompatible Magnetic Nanoparticles
Cancer Research, 12/09/09
Can human papillomavirus DNA testing of self-collected vaginal samples compare with physician-collected cervical samples and cytology for cervical cancer screening in developing countries
Cancer Epidemiology, 12/09/09
Today in Head and Neck...keeping you current
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Human papillomavirus infection and squamous cell carcinoma of the conjunctiva
British Journal of Cancer, 12/09/09
Effects of functional electrical stimulation on dysphagia caused by radiation therapy in patients with nasopharyngeal carcinoma
Supportive Care in Cancer, 12/09/09
The effectiveness of dexmedetomidine infusion for sedating oral cancer patients undergoing awake fibreoptic nasal intubation
European Journal of Anaesthesiology, 12/09/09
Today in Pharmacology/Therapy...keeping you current
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Phase II trial of temozolomide and sorafenib in advanced melanoma patients with or without brain metastases
Clinical Cancer Research, 12/09/09
A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy
Breast Cancer Research and Treatment, 12/09/09
A randomized, placebo-controlled trial (NCIC CTG MAP1) examining the effects of letrozole on mammographic breast density and other end organs in postmenopausal women
Breast Cancer Research and Treatment, 12/09/09
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