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Multimodality screening of high-risk women: A prospective cohort study
Journal of Clinical Oncology, 11/05/09

Weinstein SP et al. – Mammography has been established as the primary imaging screening method for breast cancer; however, the sensitivity of mammography is limited, especially in women with dense breast tissue. The addition of MRI to mammography in high-risk groups has the greatest potential to detect additional mammographically occult cancers. The incremental cancer yield of WBUS and DM is much less.

• During 2-year period, 609 asymptomatic high-risk women with nonactionable FSM examinations presented for prospective multimodality screening consisting of DM, WBUS, and MRI
• The FSM examinations were reinterpreted by study radiologists. Patients had benign or no suspicious findings on clinical
• The FSM examinations reinterpreted by study radiologists
• Patients had benign or no suspicious findings on clinical examination
• Cancer yield by modality evaluated

• 20 cancers were diagnosed in 18 patients (9 ductal carcinomas in situ and 11 invasive breast cancers)
• Overall cancer yield on per-patient basis was 3.0% (18 of 609 patients)
• Of 20 cancers detected, some were only detected on 1 imaging modality

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