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Snail Promotes CXCR2 Ligand–Dependent Tumor Progression in Non–Small Cell Lung Carcinoma
Clinical Cancer Research, 11/09/09
Yanagawa J et al. – As a transcriptional repressor of E–cadherin, Snail has predominantly been associated with epithelial–mesenchymal transition, invasion, and metastasis. However, other important Snail–dependent malignant phenotypes have not been fully explored. Snail upregulation plays a role in human NSCLC by promoting tumor progression mediated by CXCR2 ligands.
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Today in Basic Science/Genetics...keeping you current
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Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma
Clinical Cancer Research, 12/11/09
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Today in Lung/Thoracic Oncology...keeping you current
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Antitumor effect of BPR-DC-2, a novel synthetic cyclic cyanoguanidine derivative, involving the inhibition of MDR-1 expression and down-regulation of p-AKT and PARP-1 in lung cancer
Investigational New Drugs, 12/11/09
Influence of DNA repair RAD51 gene variants in overall survival of non-small cell lung cancer patients treated with first line chemotherapy
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Stage I nonsmall cell lung cancer in patients aged >=75 years
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