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Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress
Cancer Letters, 11/05/09
Chen Y–J et al. – Transfection of cells with GRP78 or calpain siRNA reduced honokiol–mediated cell apoptosis in JJ012 cells. Importantly, animal studies have revealed a dramatic 53% reduction in tumor volume after 21days of treatment. This study demonstrates that honokiol may be a novel anti–cancer agent targeting chondrosarcoma cells.
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