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Rapid, flow cytometric assay for NK alloreactivity reveals exceptions to rules governing alloreactivity
Biology of Blood and Marrow Transplantation, 11/05/09
De Santis D et al. – The percentage of alloreactive NK cells varied greatly between individuals and was easily estimated by the CD107a assay. For each epitope (C1, C2, Bw4), donors were found who did not have alloreactivity although alloreactivity was predicted by the current rules thought to govern alloreactivity. The data emphasize the importance of demonstrating alloreactivity in a functional assay.
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