Oncology Medical News about PTEN suppression

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UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes
Oncogene, 11/05/09

Ming M et al. – The findings indicate that (1) UVB radiation suppresses PTEN expression in keratinocytes; and (2) the ERK/AKT/PTEN axis may form a positive feedback loop following UVB irradiation. The identification of PTEN as a critical molecular target of UVB provides new insights into the pathogenesis of skin cancer.

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