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Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh
Cancer Immunology, Immunotherapy, 11/04/09
Yamasaki A et al. – In this report, the authors present for the first time that inflammation–stimulated monocytes produce Shh through activation of the NF–kappaB signaling pathway, and that the Shh produced promotes the proliferation of pancreatic cancer cells in a paracrine manner through Hh signaling.
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