Oncology Medical News about juvenile myelomonocytic leukaemia

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Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia
British Journal of Haematology, 11/04/09

Matsuda K et al. – To evaluate minimal residual disease (MRD) after chemotherapy and haematopoietic stem cell transplantation in juvenile myelomonocytic leukaemia (JMML), a locked nucleic acid–allele specific quantitative polymerase chain reaction (LNA–AS–qPCR) was developed for 13 patients. Considering the negative correlation between mutant DNA level in neonatal blood spots and age at diagnosis, JMML patients with a larger tumour burden at birth appeared to show earlier onset.

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Germ-line mutation of the NRAS gene may be responsible for the development of juvenile myelomonocytic leukaemia
British Journal of Haematology, 10/05/09 Relevance Score: 80%

Juvenile xanthogranuloma in a child with previously unsuspected neurofibromatosis type 1 and juvenile myelomonocytic leukemia
Pediatric Blood & Cancer, 10/06/09 Relevance Score: 65%

High-risk human papilloma virus infection, tumor pathophenotypes, and BRCA1/2 and TP53 status in juvenile breast cancer
Breast Cancer Research and Treatment, 10/28/09 Relevance Score: 44%

Juvenile aggressive ossifying fibroma of the maxilla
Journal of Indian Society of Pedodontics and Preventive Dentistry, 10/16/09 Relevance Score: 43%

Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia
British Journal of Haematology, 10/05/09 Relevance Score: 43%