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MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer
Medical Oncology, 11/04/09
Paule B et al. – EGFR inhibition by cetuximab may overcome the irinotecan resistance by abrogating drug efflux depending on MDR1 3435 polymorphism. Among patients resistant to irinotecan, it is still possible to use the association of cetuximab plus irinotecan to obtain a complete resection of hepatic metastases that is necessary to improve their survival.
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Today in Colorectal Cancer/Polyps...keeping you current
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A blood-based biomarker panel for stratifying current risk for colorectal cancer
International Journal of Cancer, 11/24/09
iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells
Molecular Cancer, 11/24/09
The importance of -460 C/T and +405 G/C single nucleotide polymorphisms to the function of vascular endothelial growth factor A in colorectal cancer
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Today in Pharmacology/Therapy...keeping you current
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Nuclear IRS-1 predicts tamoxifen response in patients with early breast cancer
Breast Cancer Research and Treatment, 11/24/09
Successful treatment of autoimmune and lymphoproliferative complications of patients with intrinsic B-cell immunodeficiencies with Rituximab
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