Oncology Medical News about Thrombin generation assay

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Thrombin generation assay as a possible tool for assessment of reduced activity of clotting factors induced by antiphospholipid antibodies and in-vitro evaluation of treatment options
Blood Coagulation & Fibrinolysis, 11/03/09

Livnat T et al. – The thrombin generation model showed that the addition of platelets and no recombinant factor VIIa or factor VIII inhibitor bypassing activity would correct thrombin generation in vitro. On this basis, platelet concentrates were administered to a patient with bleeding caused by lupus anticoagulant and low clotting factors activity.

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Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms
Blood, 11/12/09 Relevance Score: 66%

Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts
Arthritis & Rheumatism, 11/11/09 Relevance Score: 66%

Factor VIII contributes to platelet-fibrin thrombus formation via thrombin generation under low shear conditions
Thrombosis Research, 10/26/09 Relevance Score: 66%

A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulability in Off-Pump Coronary Surgery
Anesthesia & Analgesia, 10/21/09 Relevance Score: 65%

Involvement of human decidual cell-expressed tissue factor in uterine hemostasis and abruption
Thrombosis Research, 10/21/09 Relevance Score: 65%