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Olschwang S et al. – Predisposition to sporadic colorectal tumours is influenced by genes with minor phenotypic effects. A case–control study was set up on 295 patients treated for a large adenoma matched with polyp–free individuals on gender, age, and geographic origin in a 1 : 2 proportion. The APC p.Glu1317Gly variant appeared to influence the adenoma growth (P=.04, exact test) but not its occurrence. This result needs to be replicated and genome–wide association studies may be necessary to fully identify low–penetrance alleles involved in early stages of colorectal tumorigenesis.

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