Oncology

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Effects of chronic hepatitis C infection on the treatment of breast cancer patients
Annals of Oncology, 11/06/09

Morrow PKH et al. – Breast cancer patients with HCV can be treated with cytotoxic therapy. Comparison with historical controls showed similar rates of hepatic toxicity in the presence (or absence) of HCV, indicating that incidence of transaminitis may not be significantly affected by HCV.

• Databases of the University of Texas M.D. Anderson Cancer Center (MDACC) Tumor Registry, Department of Breast Medical Oncology, and Department of Laboratory Medicine were cross-referenced for patients with breast cancer, also identified as having HCV
• Eligible patients had diagnosis of invasive breast cancer, breast cancer treatment at MDACC, and diagnosis of HCV

• During chemotherapy, 25% of patients experienced elevations in aminotransferases and 44% of patients required dose reductions/delays in chemotherapy
• > 60% of patients who received chemotherapy demonstrated a grade 2 or greater complication
• 92% of patients able to complete number of cycles specified in the initial chemotherapy plan

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