Oncology Medical News about Gene silencing

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Gene silencing of glypican-3 in clear cell carcinoma of the ovary renders it more sensitive to the apoptotic agent paclitaxel in vitro and in vivo
Cancer Science, 11/02/09

Umezu T et al. – The results indicate that increased GPC3 expression in a clear cell carcinoma cell line may play a protective role against apoptosis, and so the downregulation of GPC3 may be a potential target to increase sensitivity to paclitaxel–induced apoptosis in clear cell carcinoma.

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Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer
Breast Cancer Research and Treatment, 11/12/09 Relevance Score: 70%

Hepatic Stellate Cell-Specific Gene Silencing Induced by an Artificial MicroRNA for Antifibrosis In Vitro
Digestive Diseases and Sciences, 11/10/09 Relevance Score: 66%

Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer
Cancer, 11/06/09 Relevance Score: 65%

RNAi-mediated silencing of ezrin gene reverses malignant behavior of human gastric cancer cell line SGC-7901
Journal of Digestive Diseases, 10/29/09 Relevance Score: 65%

Gene silencing of HPV16 E6/E7 induced by promoter-targeting siRNA in SiHa cells
British Journal of Cancer, 10/16/09 Relevance Score: 65%