Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials 4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ
Top Ten Searches
brca1 prostate-specific antigen sclc fobt egd bmi dysplasia hematologic ovarian hccYour Article Summary
See Latest ArticlesNatural course of HCV infection in childhood cancer survivors
Supportive Care in Cancer, 10/30/09
Fioredda F et al. – The goal of this study was to describe the course of hepatitis C in a cohort of 105 survivors after childhood cancer. The outcome of hepatitis C in our patients is comparable to the one described in European cohorts of adult cancer survivors and perinatally infected subjects. Nevertheless, progression to high degrees of hepatic damage has to be monitored by a careful follow-up.
Methods- Data on chemo/radiotherapy, clinical status, serial alanine aminotransferase (ALT) evaluation, and virological parameters after end of treatment were collected for each patient
- Liver biopsies, when performed, centrally evaluated by a pathologist
- All patients were alive at end of follow-up and did not show hepatic insufficiency
- ALT evaluation along entire follow-up showed moderate (87%) or a remarkable (13%) cytolytic pattern
- Young age at diagnosis, hematopoietic stem cell transplantation, and duration of infection significantly correlate with worse hepatic activity
- Type of tumor and chemo and/or radiotherapy regimens did not influence pattern of hepatic cytolysis
- Liver biopsy, centrally reviewed in 30% of cohort, showed 1 case of cirrhosis and mild fibrosis in 71% of group
- Higher degrees of fibrosis did not seem to be related to any exposition to chemo/radiotherapy but correlated significantly with more remarkable cytolytic course
Today in Pediatric Heme/Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Peripheral arterial tonometry in assessing endothelial dysfunction in pediatric sickle cell disease
Pediatric Hematology and Oncology, 11/25/09
Hepatoblastoma metastatic to the right atrium responding to chemotherapy alone
Pediatric Hematology and Oncology, 11/25/09
Association between defb1 gene haplotype and herpes viruses seroprevalence in children with acute lymphoblastic leukemia
Pediatric Hematology and Oncology, 11/25/09
Sponsor
Article Search
Sponsor
Sponsor