Oncology Medical News about Colorectal Neoplasms Folic Acid Neoplasm Recurrence, Local

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Recommendations on the use of 18F-FDG PET in oncology

3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials

4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma
American Journal of Clinical Nutrition, 10/29/09

Wu K et al. – These results do not support an overall protective effect of folic acid supplementation on adenoma recurrence. Folic acid supplementation may be beneficial among those with lower folate concentrations at baseline.

Methods

A double–blind, randomized trial among participants of 2 large prospective cohorts, the Health Professionals Follow–Up Study and the Nurses’ Health Study.
Participants were randomly assigned to receive folic acid (1 mg/d) (n = 338) or placebo (n = 334) for 3–6.5 y.
The primary endpoint was any new diagnosis of adenoma during the study period (May 1996–March 2004).
Secondary outcomes were adenoma by site, stage, and number of recurrent adenomas. Associations were also examined by plasma folate concentrations at baseline.

Results

Incidence of at least one recurrent adenoma was not significantly associated with folic acid supplementation.
Among participants with low plasma folate concentrations at baseline (<=7.5 ng/mL), those randomly assigned to receive folic acid experienced a significant decrease in adenoma recurrence, whereas for subjects with high folate concentrations at baseline (>7.5 ng/mL), supplemental folic acid had no significant effect.
Contrary to findings from another clinical trial, there was no evidence for an increased risk of advanced or multiple adenomas.

<< Previous
A phase I study to determine the safety, tolerability and maximum...

Next >>
Incidence of brain metastases in renal cell carcinoma treated...

trans-Fatty acid consumption and its association with distal colorectal cancer in the North Carolina Colon Cancer Study II
Cancer Causes and Control, 10/28/09 Relevance Score: 89%

Evaluation of Venous Invasion by Elastica van Gieson Stain and Tumor Budding Predicts Local and Distant Metastases in Patients With T1 Stage Colorectal Cancer
American Journal of Surgical Pathology, 10/28/09 Relevance Score: 88%

Resection Margin and Recurrence-Free Survival After Liver Resection of Colorectal Metastases
Annals of Surgical Oncology, 10/26/09 Relevance Score: 88%

The effect of aspirin in the recurrence of colorectal adenomas: a meta-analysis of randomized controlled trials
Colorectal Disease, 10/15/09 Relevance Score: 88%

Local Excision After Preoperative Chemoradiation Results in an Equivalent Outcome to Total Mesorectal Excision in Selected Patients with T3 Rectal Cancer
Annals of Surgical Oncology, 10/26/09 Relevance Score: 87%