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Utility of the follicular lymphoma international prognostic index and the international prognostic index in assessing prognosis and predicting first-line treatment efficacy in follicular lymphoma patients
Acta Haematologica, 11/05/09

Formica V et al. – Data from this study support the prognostic value of both IPI and FLIPI, with FLIPI demonstrating a more convenient patient distribution among risk classes. A low FLIPI score was also associated with a longer TTF. This might partially contribute to a more favourable prognosis.

• Records from patients referred with a diagnosis of follicular lymphoma retrospectively reviewed
• Data required for FLIPI and IPI scores collected along with data regarding first-line chemotherapy and time to treatment failure (TTF) and OS

• Of 162 patients screened, 130 assessable for both (FLIPI and IPI) scores
• OS for low-risk (LR) patients identified either with IPI or FLIPI significantly longer compared to intermediate-risk (IR) and high-risk (HR) groups, with FLIPI allowing a more even patient distribution among the risk groups
• For patients receiving first-line chemotherapy within 6 months of diagnosis, low FLIPI score associated with longer TTF (3-year TTF rates: 68.0, 33.7 and 31.0% for FLIPI-defined LR, IR and HR patients, respectively

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