Oncology

Your Article Summary

See Latest Articles

Age-specific differences in oncogenic pathway dysregulation and anthracycline sensitivity in patients with acute myeloid leukemia
Journal of Clinical Oncology, 11/03/09

Rao AV et al. – ML in the elderly represents a distinct biologic entity characterized by unique patterns of deregulated signaling pathway variations that contributes to poor survival and anthracycline resistance. These insights should enable development and adjustments of clinically meaningful treatment strategies in the older patient population.

• Clinically annotated microarray data from 425 patients with newly diagnosed de novo AML from two publicly available data sets were analyzed after age-specific cohorts (young 45 years, n = 175; elderly 55 years; n = 144) prospectively identified
• Gene expression analysis conducted utilizing gene set enrichment analysis, and applying previously defined and tested signature profiles reflecting dysregulation of oncogenic signaling pathways, altered tumor environment, and signatures of chemotherapy sensitivity

• Elderly AML patients as expected had worse overall survival and event-free survival compared with younger patients
• Analysis of oncogenic pathways revealed that older patients had higher probability of RAS, Src, and tumor necrosis factor (TNF) pathway activation
• Older patients less sensitive to anthracycline compared with younger patients with AML
• Hierarchical clustering revealed younger AML patients in cluster 2 had clinically worse survival, with high RAS, Src, and TNF pathway activation and were less sensitive to anthracycline compared with patients in cluster 1
• Among elderly patients with AML, those in cluster 1 also demonstrated high RAS, Src, and TNF pathway activation but this did not translate into differences in survival or anthracycline sensitivity

Today in Leukemia/Lymphoma...keeping you current

Receive free subspecialty "5-minute updates" via email

Routine use of ancillary investigations in staging diffuse large B-cell lymphoma improves the International Prognostic Index (IPI)
Journal of Hematology & Oncology, 11/25/09

Association between defb1 gene haplotype and herpes viruses seroprevalence in children with acute lymphoblastic leukemia
Pediatric Hematology and Oncology, 11/25/09

Immunochemotherapy and autologous stem-cell transplantation for untreated patients with mantle-cell lymphoma: CALGB 59909
Journal of Clinical Oncology, 11/25/09

 See all of Leukemia/Lymphoma