Oncology Medical News about tumorigenesis

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Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy
Journal of Hematology & Oncology, 10/30/09

Yuan R et al. – The mammalian target of rapamycin (mTOR) is an intracellular serine/threonine protein kinase positioned at a central point in a variety of cellular signaling cascades. The established involvement of mTOR activity in the cellular processes that contribute to the development and progression of cancer has identified mTOR as a major link in tumorigenesis. The results of ongoing clinical trials with mTOR inhibitors, as single agents and in combination regimens, will better define their activity in cancer.

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APC promoter hypermethylation is an early event in endometrial tumorigenesis
Cancer Science, 11/16/09 Relevance Score: 88%

RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1
Oncogene, 10/26/09 Relevance Score: 88%

Induction and Down-regulation of Sox17 and Its Possible Roles During the Course of Gastrointestinal Tumorigenesis
Gastroenterology, 10/07/09 Relevance Score: 88%

High Expression of the PAX3-FKHR Oncoprotein Is Required to Promote Tumorigenesis of Human Myoblasts
American Journal of Pathology, 11/09/09 Relevance Score: 83%

EBV-Induced Human CD8+ NKT Cells Suppress Tumorigenesis by EBV-Associated Malignancies
Cancer Research, 10/21/09 Relevance Score: 82%