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Protein kinase C-beta II expression in diffuse large B-cell lymphoma predicts for inferior outcome of anthracycline-based chemotherapy with and without rituximab
Leukemia and Lymphoma, 10/30/09
Chaiwatanatorn K et al. – Immunohistochemically demonstrated PKC–beta II expression thus identified patient subgroups where alternative treatment strategies may confer superior outcome. PKC–beta II expression has prognostic significance not only for CHOP therapy in low–risk IPI disease, but also for all patients receiving CHOP plus rituximab.
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Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs
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