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Comparison of liquid-based cytology with conventional cytology for detection of cervical cancer precursors: A randomized controlled trial
JAMA, 10/28/09

Siebers AG et al. – This study indicates that liquid-based cytology does not perform better than conventional Pap tests in terms of relative sensitivity and PPV for detection of cervical cancer precursors.

Methods

Cluster randomized controlled trial involving 89 784 women aged 30 to 60 years participating in Dutch cervical screening program at 246 family practices
122 practices were assigned to use liquid-based cytology and screened 49 222 patients and 124 practices were assigned to use the conventional Papanicolaou (Pap) test and screened 40 562 patients between April 2004 and July 1, 2006
Patients followed up for 18 months through January 31, 2008

Results

Adjusted detection rate ratios for CIN grade 1+ was 1.01 ; for CIN grade 2+, 1.00 ; for CIN grade 3+, 1.05 ; and for carcinoma, 1.69
Adjusted positive predictive value (PPV) ratios, considered at several cytological cutoffs and for various outcomes of CIN did not differ significantly from unity

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