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A prospective study of lifetime physical activity and prostate cancer incidence and mortality
British Journal of Cancer, 11/02/09

Orsini N et al. – The results of this study suggest that not sitting for most of the time during work or occupational activity and walking or bicycling more than 30 min per day during adult life is associated with reduced incidence of prostate cancer.

• Prospective cohort of 45 887 men aged 45–79 years followed up from January 1998 to December 2007 for prostate cancer incidence (n=2735) and to December 2006 for its subtypes and for fatal (n=190) prostate cancer

• Observed an inverse association between lifetime (average of age 30 and 50 years, and baseline age) total PA levels and prostate cancer risk
• Multivariate-adjusted incidence in top quartile of lifetime total PA decreased by 16% compared with that in bottom quartile
• Observed an inverse association between average lifetime work or occupational activity and walking or bicycling duration and prostate cancer risk
• Compared with men who mostly sit during their main work or occupation, men who sit half of time experienced a 20% lower risk
• Rate ratio linearly decreased by 7% (95% CI=1–12%) for total, 8% (95% CI=0–16%) for localised and 12% (95% CI=2–20%) for advanced prostate cancer for every 30 min per day increment of lifetime walking or bicycling in range of 30 to 120 min per day

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