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The association of metabolic syndrome with triple-negative breast cancer
Breast Cancer Research and Treatment, 10/28/09

Maiti B et al. – Metabolic syndrome, a conglomerate of obesity, insulin resistance, dyslipidemia, and hypertension has been linked with an increased risk of breast cancer. Our study suggests that metabolic syndrome is significantly more prevalent in triple-negative breast cancer patients as opposed to non-triple-negative patients

• 176 patients (including 86 triple-negatives)
• Retrospective comparison performed using Pearson Chi-square test or Student’s t test for data analysis

• Statistically significant association of triple-negative breast cancer with metabolic syndrome observed
• 58.1% of triple-negative patients had metabolic syndrome compared to only 36.7% of non-triple-negative patients
• Blood glucose, triglyceride, and HDL levels but not hypertension or BMI (body mass index) showed significant independent association with triple-negative breast cancer
• Triple-negative tumors displayed significantly higher histological grade and relative paucity of ductal carcinoma in situ (DCIS) when compared to the non-triple-negative tumors

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