Oncology Medical News about Lymphoma, B-Cell Lymphoma, Large B-Cell, Diffuse

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BCL6 regulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt
Blood, 11/09/09

Juszczynski P et al. – In "BCR–type" DLBCLs, BCL6 depletion increased PTPROt expression and decreased phosphorylation of SYK and the downstream adaptor protein, BLNK. Since BCL6 augments BCR signaling and BCL6 and SYK are both promising therapeutic targets in many DLBCLs, combined inhibition of these functionally related pathways warrants further study.

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Influence of low absolute lymphocyte count of patients with nongerminal center type diffuse large B-cell lymphoma with R-CHOP therapy
Annals of Oncology, 11/16/09 Relevance Score: 97%

Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approach
Hematological Oncology, 10/27/09 Relevance Score: 97%

Immuno-Fluorescence In Situ Hybridization Index Predicts Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A GELA Study
Journal of Clinical Oncology, 10/02/09 Relevance Score: 97%

Cyclophosphamide, doxorubicin, vincristine, methotrexate, bleomicin and prednisone plus rituximab in untreated young patients with low-risk (age-adjusted international prognostic index 0-1) diffuse large B-cell lymphoma
Leukemia and Lymphoma, 11/04/09 Relevance Score: 96%

High rate of survival in transformed lymphoma after autologous stem cell transplant: pathologic analysis and comparison with de novo diffuse large B-cell lymphoma
Leukemia and Lymphoma, 10/30/09 Relevance Score: 96%