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Intratumoral delivery of shRNA targeting cyclin D1 attenuates pancreatic cancer growth
Cancer Gene Therapy, 10/27/09
Deharvengt SJ et al. – It is concluded that lentivirus–delivered shRNA targeting cyclin D1 suppresses the growth, invasiveness, tumorigenicity and pro–angiogenic potential of human pancreatic cancer cells, thereby raising the possibility that intratumoral injections of viruses targeting cyclin D1 could provide a new therapeutic approach in pancreatic ductal adenocarcinoma.
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