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Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients
Breast Cancer Research and Treatment, 10/27/09

Hancke K et al. – Several adipocytokines, such as leptin or adiponectin, are associated with obesity and the risk for breast cancer. Adiopcyte fatty acid binding-protein (A-FABP) is another protein found in adipose tissue; therefore, this study investigated the association of A-FABP with the occurrence and prognosis of breast cancer. This study reveals that high A-FABP serum levels are associated with obesity, breast cancer risk, and adverse tumor characteristics.

Methods

200 women attending University of Ulm for breast surgery between the years 2005 and 2007 included
159 had histologically confirmed breast cancer
41 had histologically confirmed benign lesions
Serum levels of A-FABP, leptin, and adiponectin measured, and their relationship to BMI, breast cancer, and tumor characteristics were analyzed; logistic regression model was adjusted to age, BMI, menopausal status, use of HRT, and family history of breast cancer

Results

Serum A-FABP levels found to be significantly higher in obese (BMI ≥ 25) than in non-obese women (BMI ≤ 24.9), 41.16 ng/ml and 24.95 ng/ml, respectively
Independent of obesity, the serum A-FABP levels significantly higher in breast cancer patients (34.65 ng/ml) than in healthy controls (24.47 ng/ml); the odds ratio (1.038, 95% confidence interval 1.001–1.72) showed a significant association of A-FABP with breast cancer risk
Serum leptin levels showed strong correlation with BMI and were significantly higher in breast cancer patients than in controls
Adiponectin showed no significant association with breast cancer

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