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Brandal P et al. – The prognosis for patients with synchronous and metachronous skeletal osteosarcoma is poor. However, because long–term survival is seen, aggressive treatment to selected cases, e.g., patients with an osteosarcoma predisposing syndrome and/or late occurring metachronous tumours, is justified. Revealing a possible clonal relationship between these tumors, e.g., by karyotyping, may be of interest for estimating prognosis and guide therapy intensiveness.

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