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See Latest ArticlesThe expression of p53, bcl-2, bax, fas and fasL in the primary tumour and lymph node metastases of breast cancer
Acta Oncologica, 11/02/09
AuthorLastNameFI et al. – The expression of p53, bax, bcl - 2, fas and fasL is not maintained in the matching lymph node metastases of breast cancer
Methods- Immunohistochemical stainings of p53, bax, bc-l2, fas and fasL performed in primary tumours and parallel lymph node metastases
- When using a cut point of 10%, the concordance between primary tumours and parallel lymph node metastases in expression of p53 was 85%, bcl-2 79%, bax 69%, fas 59% and fasL 43%
- In most tumours staining status of p53, bcl-2 and bax in primary tumour and corresponding lymph node did not change more than 20%
- 15-25% of the cases, nodal expression was more than 20% lower than in primary tumours, while in 10-17% of cases, nodal expression was more than 20% higher than in primary tumours
- Most fasL positive tumours lost positivity in lymph node metastases or showed positively staining cancer cells only in peripheral region of node
- Phenotype analysis of combined information of tumour fas/tumour fasL/nodal fas/nodal fasL expression (+/ - ) assessed
- Most frequently observed phenotype was tumour fas - /tumour fasL + /nodal fas - /nodal fasL- (22% of the tumours), although almost all combinations seen
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