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Physical activity for the affected limb and arm lymphedema after breast cancer surgery. A prospective, randomized controlled trial with two years follow-up
Acta Oncologica, 10/27/09

Sagen A et al. – Patients that undergo breast cancer surgery with axillary lymph node dissection should be encouraged to maintain physical activity in their daily lives without restrictions and without fear of developing ALE.

• Women with a mean age of 55 ± 10 years who had axillary node dissection randomized into 2 different rehabilitation programs that lasted for 6 months
• Primary outcomes were difference in arm volume between affected and control arms (Voldiff, in ml) and the development of ALE
• Baseline (before surgery) and follow-up tests performed 3 months, 6 months, and 2 years after surgery
• Data analyzed using ANCOVA and regression analysis

• Voldiff did not differ significantly between the 2 treatment groups
• Arm volume increased significantly over time in both the affected and the control arms
• Development of ALE from baseline to 2 years increased significantly in both groups
• Only risk factor for ALE was BMI > 25 kg/m2

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