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See Latest ArticlesEGF61A > G polymorphism as predictive marker of clinical outcome to first-line capecitabine and oxaliplatin in metastatic colorectal cancer
Annals of Oncology, 10/28/09
AuthorLastNameFI et al. – Polymorphism analysis of a simple blood sample is a feasible approach to biomarker analysis and the EGF61A>G polymorphism may influence the effect of first-line XELOX. Consequently, this marker deserves further investigation.
Methods- 68 patients treated with first-line XELOX
- Polymorphism analyses carried out on pretreatment blood samples
- Response evaluated according to the RECIST
- Survival analysis described by Kaplan–Meier method and log-rank testing
- Overall response rate was 38% and median overall survival 19.4 months
- Favorable outcome seen in patients with EGF61A/G genotype compared with combined group of A/A and G/G, with response rates of 57% and 18%, respectively
- Significantly different progression-free survival in favor of A/G group
- TS and ERCC1 genotypes failed to provide any significant impact on outcome
Today in Basic Science/Genetics...keeping you current
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A risk stratification by hormonal receptors (ER, PgR) and HER-2 status in small (≤ 1 cm) invasive breast cancer: Who might be possible candidates for adjuvant treatment?
Breast Cancer Research and Treatment, 12/09/09
Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes
Breast Cancer Research, 12/08/09
DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer
Oncogene, 12/08/09
Today in Colorectal Cancer/Polyps...keeping you current
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DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer
Oncogene, 12/08/09
Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo
Molecular Cancer, 12/08/09
Case-control study on beneficial effect of regular consumption of apples on colorectal cancer risk in a population with relatively low intake of fruits and vegetables
European Journal of Cancer Prevention, 12/08/09
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