Oncology Medical News about chronic lymphocytic leukemia

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Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival and response to DNA damage
Blood, 11/09/09

Malcikova J et al. – Monoallelic defects had a negative impact on survival and impaired in vitro response to fludarabine. Mutation analysis of the TP53 should be performed before each treatment initiation since novel defects may be selected by previous therapies.

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AID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma is associated with poor prognosis and complex genetic alterations
Modern Pathology, 11/11/09 Relevance Score: 82%

Genetic lesions in chronic lymphocytic leukemia: clinical implications
Current Opinion in Oncology, 10/14/09 Relevance Score: 81%

Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells
Haematologica, 10/13/09 Relevance Score: 81%

Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia
International Journal of Hematology, 10/13/09 Relevance Score: 81%

Chronic lymphocytic leukaemia masquerading as a backache
The Internet Journal of Orthopedic Surgery, 10/12/09 Relevance Score: 81%