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Macronutrients, fatty acids, cholesterol and pancreatic cancer
European Journal of Cancer, 10/27/09

Lucenteforte E et al. – A role of diet and nutrition in pancreatic carcinogenesis has been suggested, but the association between selected macronutrients, fatty acids, cholesterol and pancreatic cancer remains controversial. A diet poor in animal proteins and rich in sugars (mainly derived from fruit) appears to have a beneficial effect on pancreatic cancer risk.

• Data analysed from a hospital-based case-control study conducted in Italy between 1991 and 2008, including 326 cases (174 men and 152 women) with incident pancreatic cancer
• 652 controls (348 men and 304 women) frequency-matched to cases by sex, age and study center
• Odds ratios (ORs) and 95% confidence intervals (CIs) estimated using multiple logistic regression models conditioned on age, sex and study centre, and adjusted for year of interview, education, tobacco smoking, history of diabetes and energy intake

• Positive association found for animal proteins
• Negative association was observed for sugars
• Non-significant negative associations emerged for vegetable proteins and polyunsaturated fatty acids

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