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See Latest ArticlesGenetic Variation in the Progesterone Receptor and Metabolism Pathways and Hormone Therapy in Relation to Breast Cancer Risk
American Journal of Epidemiology, 10/22/09
Reding KW et al. – In an analysis combining data from 2 population–based case–control studies of postmenopausal breast cancer conducted in Washington State in 1997–1999 and 2000–2004, the authors evaluated how 51 single nucleotide polymorphisms in 7 progesterone–related genes influenced breast cancer risk. There was no appreciable association with breast cancer risk overall for any single nucleotide polymorphism. For rs2854482 in AKR1C2, carrying 1 or 2 A alleles was associated with a 2.0–fold increased breast cancer risk in EPT users but not in never users. For rs12387 in AKR1C3, the presence of 1 or 2 G alleles was associated with a 1.5–fold increased risk among EPT users but not in never users. Interpretation of these subgroup associations must await the results of similar studies conducted in other populations.
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Today in Basic Science/Genetics...keeping you current
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Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma
Clinical Cancer Research, 12/11/09
Analysis of VHL Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell Carcinoma
Clinical Cancer Research, 12/11/09
Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation
British Journal of Haematology, 12/11/09
Today in Breast...keeping you current
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Hepatocyte Nuclear Factor-4–Independent Synthesis of Coagulation Factor VII in Breast Cancer Cells and Its Inhibition by Targeting Selective Histone Acetyltransferases
Molecular Cancer Research, 12/11/09
Tamoxifen Inhibits TRPV6 Activity via Estrogen Receptor–Independent Pathways in TRPV6-Expressing MCF-7 Breast Cancer Cells
Molecular Cancer Research, 12/11/09
Effects of distant metastasis and peripheral CA 15-3 on the induction of spontaneous T cell responses in breast cancer patients
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