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Lionetti M et al. – The occurrence of several allelic imbalances or loss–of–heterozygosity was found significantly associated with the altered expression of miRNAs located in the involved regions, such as let–7b at 22q13.31 or miR–140–3p at 16q22. Finally, the integrative analysis based on computational target prediction and miRNA/mRNA profiling defined a network of putative functional miRNA–target regulatory relations supported by expression data.
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