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Palliative Oncology: Thalidomide
American Journal of Hospice and Palliative Medicine, 10/21/09

Prommer EE – After decades of disuse because of its teratogenic effects, thalidomide has had a resurgence of use as a promising therapeutic agent for multiple myeloma. Its mechanism of action involves activation of the immune system, antiangiogenic effects, and inhibition of cytokines. Thalidomide does not interact with the cytochrome oxidase system. It is not significantly metabolized, but it does undergo nonenzymatic hydrolysis in plasma. The resulting products are inactive. Despite the potential adverse effects of peripheral neuropathy, constipation, deep vein thrombosis, somnolence, rash, and orthostatic hypotension, thalidomide is an effective first–line agent for multiple myeloma in combination with dexamethasone or melphalan and prednisone. It has also been studied in the palliative care of patients with cytokine–based syndromes such as anorexia–cachexia syndrome. This review describes its use in oncology, hematology, and palliative care.

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Impact of a pediatric palliative care program
Pediatric Blood & Cancer, 10/23/09 Relevance Score: 88%

A survey on physician knowledge and attitudes towards clinical use of morphine for cancer pain treatment in China
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The Role of OROS Hydromorphone in the Management of Cancer Pain
Pain Practice, 10/27/09 Relevance Score: 86%

Medical Students' Views and Ideas About Palliative Care Communication Training
American Journal of Hospice and Palliative Medicine, 10/09/09 Relevance Score: 83%