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See Latest ArticlesEnrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort
Cancer Epidemiology, Biomarkers & Prevention, 10/27/09
Middeldorp A et al. – Recent genome–wide association studies have identified several loci that confer an increased risk of colorectal cancer (CRC). The authors studied the role of the 8q24.21 (rs6983267), 18q21.1 (rs12953717), 15q13.3 (rs4779584), 11q23.1 (rs3802842), 8q23.3 (rs16892766), and 10p14 (rs10795668) risk variants in a series of 995 Dutch CRC cases and 1340 controls. The results suggest that clustering of low–risk variants may explain part of the excess risk in CRC families.
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