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See Latest ArticlesGenetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
Breast Cancer Research, 10/26/09
Neuhausen SL et al. – This is the first study to investigate the role of genetic variation in IGF signaling and breast cancer risk in women carrying deleterious mutations in BRCA1 and BRCA2. We identified significant associations in variants in IGF1R and IRS1 in BRCA1 carriers and in IGFBP2 in BRCA2 carriers.
Methods- Cohort of 1,665 adult, female mutation carriers, including 1,122 BRCA1 carriers (433 cases) and 543 BRCA2 carriers (238 cases)
- Genotyped for single nucleotide polymorphisms (SNPs) in IGF1, IGF1 receptor (IGF1R), IGF1 binding protein (IGFBP1), IGFBP2, IGFBP5, and IGF receptor substrate 1 (IRS1)
- Cox proportional hazards regression used to model time from birth to diagnosis of breast cancer for BRCA1 and BRCA2 carriers separately
- For linkage disequilibrium (LD) blocks with multiple SNPs, an additive genetic model assumed and for single SNP analyses no additivity assumptions made
- Among BRCA1 carriers, significant associations found between risk of breast cancer and LD blocks in IGF1R
- Among BRCA2 carriers, an LD block in IGFBP2 was found to be associated with time to breast cancer diagnosis
- No significant LD block associations found for other investigated genes among BRCA1 and BRCA2 carriers
Today in Basic Science/Genetics...keeping you current
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HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy
BMC Cancer, 12/20/09
Telomere shortening and chromosomal instability in myelodysplastic syndromes
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The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation
Journal of Thrombosis and Haemostasis, 12/20/09
Today in Breast...keeping you current
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The risk for breast cancer is not evidently increased in women with hyperprolactinemia
Pituitary, 12/20/09
Extracellular Signal–Regulated Kinase Signaling Pathway Regulates Breast Cancer Cell Migration by Maintaining slug Expression
Cancer Research, 12/20/09
Invasion of Human Breast Cancer Cells In vivo Requires Both Paracrine and Autocrine Loops Involving the Colony-Stimulating Factor-1 Receptor
Cancer Research, 12/19/09
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