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Jazieh AR et al. – This study aim was to determine the efficacy and safety of the combination of Gemcitabine 1000mg/m^2 day 1 & 8 and Irinotecan 100 mg/m^2 day 1 & 8 with escalating dose of thalidomide in chemonaive patients with advanced non–small cell lung cancer. The 1 year and 2 year survival rates were 36% and 27%, respectively. This combination is active in advanced NSCLC with manageable toxicity profile.

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