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Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors
British Journal of Cancer, 10/26/09
Kumar R et al. – Activity against c–kit and Flt–3 by multikinase angiogenesis inhibitors provide a potential explanation for the differences in myelosuppression observed with these agents in patients.
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Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs
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