Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials 4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ
Top Ten Searches
brca1 prostate-specific antigen sclc fobt egd bmi dysplasia hematologic ovarian hccYour Article Summary
See Latest ArticlesTargeting HER2 in breast cancer: overview of long-term experience
International Journal of Women's Health, 10/20/09
Lantz E et al. – The ability to probe diseases at the genomic level has improved our understanding and enhanced the treatment of breast cancer. One important finding relates to the HER2 oncogene which encodes a novel transmembrane receptor that, when overexpressed, appears to confer growth and survival advantages to breast tumor cells. This fortuitous discovery enabled researchers to develop agents which could inhibit receptor–mediated tumor cell signaling. Numerous clinical trials of such agents have demonstrated improved outcomes in patients with HER2–positive breast cancer. Nonetheless, not all tumors respond to therapy targeting the receptor, while relapses occur after an initial response to treatment. This paper provides a historical and current perspective of the treatment of patients with HER2–positive breast cancer.
Related Articles
Genetic Variation in the Progesterone Receptor and Metabolism Pathways and Hormone Therapy in Relation to Breast Cancer Risk
American Journal of Epidemiology, 10/22/09
Relevance Score: 80%
Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer
Breast Cancer Research and Treatment, 11/12/09
Relevance Score: 71%
Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers
Journal of Clinical Oncology, 10/29/09
Relevance Score: 70%
Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1
Breast Cancer Research and Treatment, 10/29/09
Relevance Score: 69%
Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility
BMC Cancer, 10/09/09
Relevance Score: 68%
Today in Breast...keeping you current
Receive free subspecialty "5-minute updates" via email
Gene expression of ERbeta isoforms in laser microdissected human breast cancers: Implications for gene expression analyses
Cellular Oncology, 12/07/09
Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression
Cellular Oncology, 12/07/09
Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients
Cellular Oncology, 12/07/09
Today in Pharmacology/Therapy...keeping you current
Receive free subspecialty "5-minute updates" via email
Triweekly Oxaliplatin Plus Oral Capecitabine as First-Line Chemotherapy in Elderly Patients With Advanced Gastric Cancer
American Journal of Clinical Oncology, 12/07/09
Impact of anti-angiogenic treatments on metastatic renal cell carcinoma
Expert Review of Anticancer Therapy, 12/07/09
Role and rationale of gene therapy and other novel therapies in the management of NMIBC
Expert Review of Anticancer Therapy, 12/07/09
Sponsor
Article Search
Sponsor
Sponsor