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CD3+ and/or CD14+ depletion from cord blood mononuclear cells before ex vivo expansion culture improves total nucleated cell and CD34+ cell yields
Bone Marrow Transplantation, 10/23/09
Yang H et al. – Ready translation of this depletion strategy to improve ex vivo CB expansion in the clinic is feasible as clinical–grade devices and reagents are available. Ultimately, the aim of improving TNC and CD34+ transplant doses is to further improve the rate of neutrophil and platelet engraftment in CB recipients.
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Today in BMT/SCT...keeping you current
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The number of infused CD34+ cells does not influence the incidence of GVHD or the outcome of allogeneic PBSC transplantation, using reduced-intensity conditioning and antithymocyte globulin
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Today in Basic Science/Genetics...keeping you current
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