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See Latest ArticlesThe Rap GTPases regulate the migration, invasiveness and in vivo dissemination of B-cell lymphomas
Oncogene, 10/26/09
Lin KBL et al. – In vitro assays showed that Rap activation is required for A20 cells to efficiently adhere to vascular endothelial cells and undergo transendothelial migration. These findings suggest that Rap or its effectors could be novel targets for treating B–cell lymphomas.
MR Gold, 10/29/09
| Lin KBL et al. – In vitro assays showed that Rap activation is required for A20 cells to efficiently adhere to vascular endothelial cells and undergo transendothelial migration. These findings suggest that Rap or its effectors could be novel targets for treating B–cell lymphomas. Consistent with this idea, in vivo experiments showed that Rap activation is important for B lymphoma cells to exit the circulation, colonize the liver, and form tumors in mice. |
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