Oncology Medical News about Notch-1

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Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells
Oncogene, 10/26/09

Hao L et al. – CSL binding elements frequently occur in close proximity to estrogen–responsive elements (EREs) in the human and mouse genomes. The observations suggest that a hitherto unknown Notch–1/ERalpha chromatin crosstalk mediates Notch signaling effects in ERalpha–positive breast cancer cells and contributes to regulate the transcriptional functions of ERalpha itself.

Exclusive Author Commentary
L Miele, 10/26/09

The potential clinical relevance of these observations is that Notch signaling may be a hitherto unrecognized mechanism for endocrine-resistance in ERalpha-positive breast cancer. This in turn has potential implications from the diagnostic/prognostic standpoint as well as from the therapeutic standpoint, since at least 2 Notch inhibitors are currently in early clinical trials in oncology.

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