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Efficacious but insidious: A retrospective analysis of fludarabine-induced myelotoxicity using long-term culture?initiating cells in 100 follicular lymphoma patients
Experimental Hematology, 10/22/09
Janikova A et al. – Fludarabine and procarbazine have a dramatic influence, especially on the most immature hematopoietic cells, mirrored in reduced numbers of LTC–IC. This finding is consistent with clinical observations (poor mobilization after fludarabine) and offers an insight into the mechanism of fludarabine–induced myelotoxicity.
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